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Rheumatology 2001; 40: 111-112
© 2001 British Society for Rheumatology

Letters to the Editor

Antiphospholipid antibody system in systemic sclerosis

A. Parodi, M. Drosera, L. Barbieri1 and A. Rebora

DiSEM Section of Dermatology, University of Genoa, Viale Benedetto XV no. 7, 16132 Genoa and
1 Bouty s.p.a., Milan, Italy

The first 10% of the full text of this article appears below.

SIR, Anti-phospholipid antibodies (aPLa) are a heterogeneous family of immunoglobulins directed to negatively charged phospholipids binding particular plasma proteins that behave as co-factors, e.g. ß 2 glycoprotein I (ß 2-GPI), prothrombin, protein C, protein S and annexin V. aPLa characterize the anti-phospholipid syndrome with thrombosis, thrombocytopenia and recurrent spontaneous abortions, but they can also be detected in connective tissue diseases, in particular systemic lupus erythematosus, and, more rarely, in lymphoproliferative disorders and infectious diseases . . . [Full Text of this Article]


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