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Rheumatology 2001; 40: 831-832
© 2001 British Society for Rheumatology

Letters to the Editor

Azathioprine toxicity mimicking a relapse of Wegener's granulomatosis

E. Reinhold-Keller, W. H. Schmitt and W. L. Gross

Department of Rheumatology, University of Lübeck and Rheumaklinik Bad Bramstedt, Germany

SIR, We report a patient with severe generalized Wegener's granulomatosis (WG) including crescentic glomerulonephritis (GN) at diagnosis, in whom maintenance of remission therapy with azathioprine resulted in acute deterioration of renal function combined with high fever, constitutional symptoms, rheumatic complaints and an increase in inflammatory parameters mimicking a relapse of WG. We report this case to heighten awareness that symptoms reminiscent of a vasculitis relapse can be caused by azathioprine toxicity.

The diagnosis of WG was established in December 1996 in a 63-yr-old man with GN (serum . . . [Full Text of this Article]

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