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Rheumatology 2001; 40: 1068-1070
© 2001 British Society for Rheumatology

Letters to the Editor

The influence of current cigarette smoking on the age of onset of rheumatoid arthritis (RA) in individuals with sporadic and familial RA

D. Hutchinson, M. P. Lynch, R. J. Moots, R. N. Thompson and E. Williams

Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmore Lane, Liverpool L9 7AL, UK

SIR, We read with interest the paper by Radstake et al. [1] entitled ‘Familial vs sporadic rheumatoid arthritis (RA). A prospective study in an early RA inception cohort’. The main finding of this study was that sibship size is the only relevant risk factor associated with familial RA. No differences in genotypic and phenotypic characteristics, disease severity or radiological damage were observed when comparing familial and sporadic RA in the population studied overall. However, following stratification for gender, males with sporadic RA were older at disease onset than male probands with familial RA [median (range) 57 (24–78) vs 50 (24–61) yr, P=0.03]. This was not the case regarding female RA cases.

We would suggest that a history of . . . [Full Text of this Article]

Notes

References

T. R. D. J. Radstake and P. Barrera

Department of Rheumatology, University Hospital Nijmegen, PO Box 9101, 65500 HB Nijmegen, The Netherlands


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The influence of current cigarette smoking on the age of onset of rheumatoid arthritis (RA) in individuals with sporadic and familial RA
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