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Rheumatology 2002; 41: 1330-1332
© 2002 British Society for Rheumatology

Letters to the Editor

Is methotrexate effective in ankylosing spondylitis?

B. Roychowdhury, S. Bintley-Bagot1, D. Y. Bulgen2, R. N. Thompson3, E. J. Tunn and R. J. Moots3

Rheumatology and
1 Physiotherapy Departments, Royal Liverpool University Hospital,
2 Rheumatology Department, Countess of Chester Hospital and
3 Rheumatology Department, University Hospital Aintree, UK

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SIR, Ankylosing spondylitis (AS) is a chronic inflammatory condition that causes chronic back pain and spinal fusion, often resulting in severe disability and increased morbidity. Whilst non-steroidal anti-inflammatory drugs (NSAIDs) are the mainstay of treatment, they only offer symptomatic aid and there is a pressing need for drugs that affect the disease process itself. Of potential disease modifying drugs, sulphasalazine [1] has shown some short-term benefit in alleviating symptoms of spinal pain and morning stiffness, but this appears to be transient at best. Methotrexate, used extensively in rheumatoid . . . [Full Text of this Article]


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