Rheumatology 2002; 41: 1450-1452
© 2002 British Society for Rheumatology
Paediatric Rheumatology |
Anti-tumour necrosis factor therapy associated with cutaneous vasculitis
Paediatric Rheumatology Unit, Great Ormond St Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
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SIR, We read with interest the letter by McCain et al. [1] and we wish to add our experience of a case of probable vasculitis or cutaneous reaction secondary to anti-tumour necrosis factor (anti-TNF) therapy, as has been noted by others. While injection site reactions can occur in up to 20% of patients receiving etanercept [2], more generalized reactions are only recently being recognized [1, 36].
We report a Caucasian girl who was referred to our rheumatology unit at 9
yr of age in October 1995 with a 6-month history of intermittent daily high-spiking fever, lethargy, evanescent rash accompanying the fever, and joint pain and stiffness. Clinical
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