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Rheumatology 2002; 41: 364-366
© 2002 British Society for Rheumatology

Editorials

Family studies in systemic lupus erythematosus

M. E. Alarcón-Riquelme

Institute of Genetics and Pathology, Section for Medical Genetics, Rudbeck Laboratories, University of Uppsala, Dag Hammarsjölds väg 20, 751 85 Uppsala, Sweden

Most diseases have a genetic basis. How genes are involved varies greatly from case to case and their products may play a major or a secondary role in disease development. Traditionally, the genetics of common diseases has been analysed through association studies. Many of these studies have used only small sets of patients and have rarely attempted replication in independent sets. Their significance is difficult to assess as the results are in many instances inconclusive, particularly when other researchers have attempted replication in a different population. Success stories include the association between HLA-B27 and ankylosing spondylitis, and the association of DRß1*04 alleles with rheumatoid arthritis. The main reason for these successes has been the happy coincidence between the interest in HLA at the time, the fact that HLA is indeed of importance in diseases of immunological pathogenesis, and the strong and unusual linkage disequilibrium of the MHC region . . . [Full Text of this Article]

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