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Rheumatology 2002; 41: 586-588
© 2002 British Society for Rheumatology

Letters to the Editor

Cardiac autonomic dysfunction precedes the development of fibrosis in patients with systemic sclerosis

D. Cozzolino, C. Naclerio1, R. Iengo1, S. D'Angelo1, G. Cuomo1 and G. Valentini1,

Department of Geriatrics and Metabolic Diseases and
1 Rheumatology Unit, Second University of Naples, Naples, Italy

SIR, In recent years, clinicians involved in scleroderma research have proposed the identification of a subset of systemic sclerosis (SSc) to be named ‘pre-scleroderma’, which is characterized by Raynaud's phenomenon plus nailfold capillary changes, disease-specific circulating antinuclear autoantibodies (anti-topoisomerase-1, anti-centromere or nucleolar), and digital ischaemic changes [1]. Here, we report two patients with pre-scleroderma in . . . [Full Text of this Article]

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