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Rheumatology 2002; 41: 697-698
© 2002 British Society for Rheumatology

Paediatric Rheumatology

Antiphospholipid syndrome in an eight-month-old infant with sickle cell trait

Paediatric Rheumatology/Series Editor: P. Woo

Letters to the Editor

R. Pocurull, C. J. Lozada, C. Gordon, E. Steigelfest and C. Alonso

Division of Rheumatology and Immunology, University of Miami School of Medicine, Miami, Florida, USA

SIR, Antiphospholipid syndrome (APS) can demonstrate a range of clinical presentations from recurrent miscarriages to thrombosis [1]. It primarily affects women and is more common in patients with a history of autoimmune disease. Criteria for APS classification have been published [2]. These include vascular thrombosis, pregnancy morbidity, and the presence of anticardiolipin antibodies (ACA) of the IgG or IgM type and/or lupus anticoagulant (LAC).

APS is an uncommon disorder in children. Here we describe the youngest individual yet reported with native antibodies and cerebral vascular thrombosis due to APS. An 8-month-old previously healthy female infant presented with . . . [Full Text of this Article]

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