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Rheumatology 2002; 41: 725-729
© 2002 British Society for Rheumatology

Review

Genetic studies of disorders of calcium crystal deposition

A. E. Timms1, Y. Zhang1, R. G. G. Russell2 and M. A. Brown1,2,

1 Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN and
2 Oxford University Institute of Musculoskeletal Sciences, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK

The first 150 words of the full text of this article appear below.


   Introduction
 
Disordered calcification of cartilage and ligaments occurs commonly amongst the elderly, yet the reasons for this are very poorly understood. Chondrocalcinosis affects 25% of the population aged over 85 yr and 3% of people aged between 65 and 69 yr show radiological evidence of the disease [1]. Diffuse idiopathic skeletal hyperostosis (DISH, Forestier's disease), which causes ossification of the anterior longitudinal spinous ligament and peripheral entheses, has been reported to be as prevalent as 25% in males and 15% in females over the age of 50 yr [2]. In Asian populations, in particular amongst Japanese, a similar condition, ossification of the posterior longitudinal ligament (OPLL) has a prevalence of 1.9–4.3% [3]. OPLL and DISH commonly occur together: Resnick et al. [4] have reported that 50% of cases of DISH are associated with some degree of OPLL. Although many cases of these . . . [Full Text of this Article]


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Y. Zhang, M. A. Brown, C. Peach, G. Russell, and B. P. Wordsworth
Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis
Rheumatology, April 1, 2007; 46(4): 586 - 589.
[Abstract] [Full Text] [PDF]