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Rheumatology 2003; 42: 487-488
© 2003 British Society for Rheumatology

Letters to the Editor

Complement receptor expression of relevance to apoptotic cell clearance in SLE

A. P. Cairns, A. D. Crockard1 and A. L. Bell

The Lupus Research Group, Queen's University of Belfast Musculoskeletal Education and Research Unit, Department of Rheumatology, Musgrave Park Hospital, Belfast BT9 7JB, Northern Ireland and
1 Regional Immunology Service, Royal Victoria Hospital, Belfast, Northern Ireland, UK

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SIR, The autoantigens of human systemic lupus erythematosus (SLE) are exposed on the surface of apoptotic cells and increased numbers of apoptotic cells in SLE may contribute to autoantigen generation [1]. Apoptotic cells and bodies are normally rapidly recognized and cleared, especially by local monocyte-derived macrophages, thus limiting the possibility of antigenic exposure. The mechanisms of recognition, engulfment and clearance of apoptotic cells by macrophages are being defined, and . . . [Full Text of this Article]


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A. L. Hepburn, J. C. Mason, and K. A. Davies
Expression of Fc{gamma} and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis
Rheumatology, May 1, 2004; 43(5): 547 - 554.
[Abstract] [Full Text] [PDF]