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Rheumatology 2003; 42: 596-598
© 2003 British Society for Rheumatology

Paediatric Rheumatology

Systemic juvenile idiopathic arthritis, Kikuchi's disease and haemophagocytic lymphohistiocytosis—is there a link? Case report and literature review

A. V. Ramanan, R. F. Wynn1, A. Kelsey2 and E. M. Baildam

Departments of Paediatric Rheumatology
1 Paediatric Haematology and
2 Paediatric Histopathology, Royal Manchester Children's Hospital, Charlestown Road, Blackley, UK

The first 10% of the full text of this article appears below.

SIR, Necrotizing lymphadenitis (Kikuchi's disease) is a benign cervical lymphadenopathy that typically affects young women and usually remits spontaneously with no recurrences [1]. Histology of involved lymph nodes shows a characteristic picture [2–6]. Systemic juvenile idiopathic arthritis (JIA) accounts for 10–20% of JIA, affecting males and females equally and occurring most frequently under the age of 5 yr. Generalized lymphadenopathy is found in 70–80% of cases [7, 8]. There are very few reports in the literature of systemic JIA being associated with Kikuchi's disease. One report describes three cases of adult-onset Still's disease associated with Kikuchi's disease [9]. There is only one report in children and . . . [Full Text of this Article]


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A. V. Ramanan and A. A. Grom
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A. S. M. Jawad
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 Rheumatology (Oxford)Home page
A. V. Ramanan, R. F. Wynn, A. Kelsey, and E. M. Baildam
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Rheumatology, February 1, 2004; 43(2): 254 - 255.
[Full Text] [PDF]