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Rheumatology 2003; 42: 599-600
© 2003 British Society for Rheumatology

Letters to the Editor

Severe spongiform aortic stenosis in monozygotic twins with anti-phospholipid syndrome related to systemic lupus erythematosus

S. Chandar, S. Riminton1, J. Yiannikas and L. Kritharides

Departments of Cardiology and
1 Immunology, Concord Repatriation General Hospital, University of Sydney, Australia

The first 10% of the full text of this article appears below.

SIR, Monozygotic twin concordance rate for systemic lupus erythematosus (SLE) is 24–57% with an overall population prevalence of 0.2% suggesting a dominant role of genetic predisposition to SLE susceptibility [1]. Genetic contribution to the incidence of SLE needs to be distinguished from that to the individual target organ injury within the disease. In a mouse model, the Sle 3 allele was necessary for renal manifestations of the disease [2]. Few familial associations of the anti-phospholipid syndrome (APS) have been . . . [Full Text of this Article]


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