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Rheumatology 2003; 42: 692-693
© 2003 British Society for Rheumatology

Letters to the Editor

Moderate-impact exercise is associated with decreased severity of experimental osteoarthritis in rats

L. Galois1,2, S. Etienne1, L. Grossin1, C. Cournil1, A. Pinzano1, P. Netter1, D. Mainard1,2 and P. Gillet1,

1 UMR 7561 CNRS, University of Nancy I and
2 Department of Orthopedic Surgery, University Hospital of Nancy, France

The first 10% of the full text of this article appears below.

SIR, We read with interest the article by Manninen et al. [1] reporting that moderate physical exercise is associated with a decreased risk of knee osteoarthritis (OA). We have recently investigated the influence of moderate exercise on the course of an OA model induced by anterior cruciate ligament transection (ACLT) in the rat. ACLT, a well-known model of OA that was characterized initially in various species (e.g. dog, rabbit, monkey [2]), has recently been validated in the rat [3].

Sixty male Wistar rats (200 g) underwent ACLT . . . [Full Text of this Article]


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