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Rheumatology 2003; 42: 804-805
© 2003 British Society for Rheumatology

Letters to the Editor

Development of systemic lupus erythematosus in a young child affected with chronic granulomatous disease following withdrawal of treatment with interferon-{gamma}

R. Badolato, L. D. Notarangelo, A. Plebani and D. Roos1

Clinica Pediatrica dell'Università di Brescia, Brescia, Italy and
1 Sanquin Research at CLB, and Landsteiner Laboratory of the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

The first 10% of the full text of this article appears below.

SIR, Chronic granulomatous disease (CGD) is an inherited condition characterized by impairment of phagocyte microbicidal activity owing to a reduced ability of granulocytes to synthesize superoxide ions and hydrogen peroxide, leading to recurrent bacterial and fungal infections [1]. In addition to chronic complications, CGD patients may develop other inflammatory symptoms that affect gastrointestinal and urinary systems, and/or autoimmune diseases, including inflammatory bowel disease [1, 2]. Prevention of life-threatening infections with fungal and bacterial pathogens in CGD is based . . . [Full Text of this Article]


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