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Rheumatology 2003; 42: 900-901
© 2003 British Society for Rheumatology

Letters to the Editor

Acute myelogenous leukaemia following etanercept therapy

G. Bakland1 and H. Nossent1,2,

1 Department of Rheumatology, University Hospital Tromsø and
2 Institute for Clinical Medicine, University of Tromsø, Norway

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SIR, Tumour necrosis factor-{alpha} (TNF-{alpha}) blocking agents have become increasingly popular in the treatment of chronic polyarthritis. While approved for patients with severe (juvenile) rheumatoid arthritis (RA) that is resistant to disease-modifying anti-rheumatic drugs (DMARDs), they are under investigation in seronegative spondylarthritis and vasculitis [1–4]. They increase infectious complications, especially extrapulmonary tuberculosis, but no increases in the occurrence of malignancies have been described so far [5–8]. We report the development of acute myelogenous . . . [Full Text of this Article]


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