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Rheumatology 2003; 42: 903-905
© 2003 British Society for Rheumatology

Letters to the Editor

Inflammation is a feature of the disease process in early knee joint osteoarthritis

T. Saxne1,2,, M. Lindell1,2, B. Månsson1,2, I. F. Petersson3 and D. Heinegård2

Departments of
1 Rheumatology and
2 Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, Lund and
3 Spenshult's Hospital for Rheumatic Diseases, Halmstad, Sweden

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SIR, Traditionally osteoarthritis (OA) has been considered a process involving a disturbance of the normal balance between degradation and repair in the articular cartilage and subchondral bone. In contrast to rheumatoid arthritis where inflammation, both local and systemic, is a key feature, OA is considered a primarily non-inflammatory condition. The clinical signs of low-grade inflammation that are seen in some patients, representing later stages of the process, have been thought to reflect secondary events in the joint. This view has been questioned and in a . . . [Full Text of this Article]


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