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Rheumatology Advance Access originally published online on July 16, 2003
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Rheumatology 2004; 43: 122-130
© British Society for Rheumatology 2003; all rights reserved

Review

T-cell involvement in osteoclast biology: implications for rheumatoid bone erosion

D. O’Gradaigh and J. E. Compston

Bone Research Group, University of Cambridge School of Clinical Medicine, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

Correspondence to: D. O’Gradaigh, Bone Research Group, University of Cambridge School of Clinical Medicine, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. E-mail: dogradaigh@camrheum.fsnet.co.uk

The first 150 words of the full text of this article appear below.


   Introduction
 
Erosion of periarticular bone is a hallmark of rheumatoid arthritis (RA), resulting in significant joint deformity, pain and disability [1]. Osteoclasts are specialized cells of the macrophage lineage responsible for bone resorption during remodelling. These cells have been demonstrated at the site of erosion in RA [2, 3] and in representative animal models of the disease [4], and are thus believed to be critical in the pathogenesis of joint damage. Developments in research methods have facilitated significant advances in the understanding of osteoclast regulation in conditions characterized by excessive bone resorption, including RA. As the osteoblast-derived signal that regulates osteoclasts [receptor activator of nuclear factor {kappa}B ligand (RANKL); see below] is identical to TRANCE (tumour necrosis factor-related activation-induced cytokine), which was first discovered in studies of T cells [5, 6], the intriguing role of T cells in bone biology has . . . [Full Text of this Article]


   Bone remodelling
 

   T-cell interaction with dendritic cells
 

   T-cell activation of osteoclasts in disease
 

   Adult periodontal disease: a paradigm of T-cell-mediated bone loss
 

   RANKL expression in RA
 

   T cells in oestrogen-deficient osteoporosis
 

   Interferon-{gamma}
 

   Other cytokines expressed or regulated by T cells
 

   Osteopontin
 

   Therapeutic strategies
 

   Summary
 

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This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
D. O'Gradaigh and J. E. Compston
Comment on review on T cells in bone biology: reply
Rheumatology, October 1, 2004; 43(10): 1314 - 1315.
[Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. D. Smith
Comment on review on T cells in bone biology
Rheumatology, October 1, 2004; 43(10): 1314 - 1314.
[Full Text] [PDF]