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Rheumatology Advance Access originally published online on August 23, 2005
Rheumatology 2005 44(10):1207-1209; doi:10.1093/rheumatology/kei027
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

EDITORIAL

Arthritis and inflammatory eye disease

R. C. Bucknall

Rheumatic Diseases Unit, Link 7C, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK

Correspondence to: R. C. Bucknall. E-mail: roger.bucknall@rlbuht.nhs.uk

The first 150 words of the full text of this article appear below.

The rheumatologist ignores the association between connective tissues diseases and the eye at his or her peril. Failure to recognize the significance of temporal headaches indicative of temporal arteritis in patients with polymyalgia rheumatica may result in acute loss of vision with blindness. In contrast, visual symptoms may only present when irreversible damage to the eye has occurred, as in the case of the insidious onset of intermediate uveitis in children with pauci-articular JCA with a positive ANA.

Abnormal connective tissue components such as collagen or fibrillin (in the case of Marfan's syndrome) may lead to different forms of arthropathy and visual loss depending on the type of collagen in the tissues involved. For example, defective synthesis of type I collagen leads to osteoporosis and blue sclera in osteogenesis imperfecta. In the very rare condition of osteoporosis–pseudoglioma syndrome, where there is a mutation in the low-density lipoprotein receptor-related protein 5 . . . [Full Text of this Article]


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