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Rheumatology 2006 45(1):9-10; doi:10.1093/rheumatology/kei237
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EDITORIAL

Vaccinate your immunocompromised patients!

T. Glück

Klinikum der Universität Regensburg, Franz-Josef-Strauss-Allee, 93042 Regensburg, Germany

Correspondence to: thomas.glueck@klinik.uni-regensburg.de

The first 10% of the full text of this article appears below.

Patients with rheumatoid arthritis and other chronic rheumatic diseases are at approximately doubled risk of infection compared with the normal population [1]. This may be in part due to still ill-defined immunoregulatory abnormalities associated with rheumatic diseases, but is certainly in large part secondary to the immunosuppressive therapy administered to these patients in the best interest of their joints, with proven efficacy in delaying joint destruction. The effect of disease-modifying therapies on the immune system, however, may be quite dramatic, especially if aggressive protocols such as Fauci's are administered, and they may lead to opportunistic infections otherwise only seen in patients with advanced HIV infection [2]. Inhibition of lymphocyte . . . [Full Text of this Article]


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