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Rheumatology Advance Access originally published online on July 31, 2006
Rheumatology 2006 45(10):1307-1308; doi:10.1093/rheumatology/kel250
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

LETTERS TO THE EDITOR

Clinical improvement with infliximab in a child with amyloidosis secondary to familial Mediterranean fever

S. Yüksel, F. Yalçinkaya, B. Acar, Z. B. Özçakar, B. Öztürk and M. Ekim

Department of Paediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey

Correspondence to: F. Yalçinkaya, Ankara Universitesi Tip Fakultesi Cebeci Hastanesi, Cocuk Nefroloji Bilim Dali, 06100 Dikimevi, Ankara, Turkey. E-mail: yalcinkaya@tr.net

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SIR, The most serious and fatal complication of familial Mediterranean fever (FMF) is amyloid A (AA) amyloidosis, usually affecting the kidneys, resulting in renal insufficiency progressing to end-stage renal disease. Amyloidosis may also affect the gastrointestinal tract, liver, spleen and other organs. Here, we present a case of FMF complicated by protracted arthritis, severe renal and gastrointestinal amyloidosis in which treatment with infliximab is associated with the clinical improvement of amyloidosis, in addition to complete resolution of protracted arthritis.

. . . [Full Text of this Article]


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