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Rheumatology Advance Access originally published online on September 23, 2006
Rheumatology 2006 45(12):1461-1465; doi:10.1093/rheumatology/kel329
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

REVIEW

Autoimmunity vs autoinflammation in Behcet's disease: do we oversimplify a complex disorder?

H. Direskeneli

Division of Rheumatology, Faculty of Medicine, Marmara University, Istanbul, Turkey.

Correspondence to: H. Direskeneli, Division of Rheumatology, Marmara University Hospital, Tophanelioglu Cad. 13/15, Altunizade, Istanbul, Turkey. E-mail: direskeneli@superonline.com

KEY WORDS: Behcet's disease, Innate, Adaptive, Pathogenesis

The first 150 words of the full text of this article appear below.


   Introduction
 
Behcet's disease (BD) is a systemic inflammatory disorder with a diverse spectrum of clinical manifestations including mucocutaneous, ocular, vascular, gastrointestinal, musculoskeletal and central nervous system involvement [1]. A complex genetic background leading to a pro-inflammatory, innate-immune-system-derived activation perpetuated by adaptive immune responses against enviromental and auto-antigens is accepted to be the hallmark of BD [2]. This review aims to make an in-depth critical analysis of current data for recent controversies on the role of innate immune system vs autoimmunity in BD [3–5].


   Recent epidemiological data
 
Although epidemiological data is scarse in BD, some recent observations from Japan suggest that the prevalence of BD is reducing among uveitis patients (23.2% in 1981–1983 vs 5.8% in 1999–2001) and the disease is becoming milder (ocular attacks and vision loss getting less frequent) [6, 7]. Since the genetic background of the Japanese population at risk is accepted to . . . [Full Text of this Article]


   Infectious aetiology
 

   Autoimmunity and BD
 

   Autoinflammation and BD
 

   Pathways from innate to adaptive responses
 

   Future pathways to explore
 

   Conclusions
 

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