Rheumatology Advance Access originally published online on July 31, 2006
Rheumatology 2006 45(9):1058-1061; doi:10.1093/rheumatology/kel230
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
EDITORIAL |
Corticosteroids in the management of early and established rheumatoid disease
1Department of Rheumatology, Southern General Hospital and 2Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Scotland, UK
Correspondence to: Dr Elaine Morrison, Consultant Physician & Rheumatologist, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF. E-mail: elaine.morrison@sgh.scot.nhs.uk
| The first 150 words of the full text of this article appear below. |
Corticosteroid use in rheumatoid arthritis (RA) remains something of a dichotomy to most rheumatologists. How do we reconcile the promise of disease-modifying activity in early disease with the possibility of significant and potentially long-lasting adverse effects? Is the benefit of the former sufficiently marked to justify the latter? In addition, since the debate concerning corticosteroid use in RA was re-ignited some years ago, ideas about the management of RA have moved on. More intense use of disease-modifying anti-rheumatic drugs (DMARDs), either singly or in combination, and the proliferation of anti-tumour necrosis factor (TNF-
) agents have had an enormous impact on how we now manage RA [1, 2]. Where do corticosteroids fit into our current treatment strategies?
RA has also emerged as an independent risk factor for atherosclerosis over and above those more traditionally recognised (e.g. hypertension, diabetes mellitus, weight and lipid profile) as a link between
Corticosteroid use in early RA
Efficacy
Toxicity
Corticosteroid use in established RA
Does route of administration of corticosteroids matter?
Corticosteroids and cardiovascular risk
Summary
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