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Rheumatology Advance Access originally published online on August 27, 2006
Rheumatology 2007 46(1):1-2; doi:10.1093/rheumatology/kel303
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EDITORIALS

Lymphoma and rheumatoid arthritis—again

D. P. M. Symmons

Professor of Rheumatology and Musculoskeletal Epidemiology, University of Manchester, Manchester M13 9PT, UK

Correspondence to: Prof. D. P. M. Symmons, ARC Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK E-mail: deborah.symmons@manchester.ac.uk

The first 150 words of the full text of this article appear below.

The link between lymphoma and rheumatoid arthritis (RA) continues to intrigue. It was first noted in a record linkage study from Finland published in 1978 [1]. Since then, there have been numerous reports of an increased incidence of lymphoma—in particular, non-Hodgkin's lymphoma (NHL) and more particularly diffuse large B-cell lymphoma (DLBCL) [2]—in patients with RA from around the world [3–6]. It can now be considered beyond dispute that RA and, indeed, many other autoimmune diseases are associated with an increased risk of NHL. However, the question remains as to the relative contribution of the underlying disease and the drugs used to treat it to the aetiology of the malignancy. The advent of each new treatment for RA seems to re-open the debate.

There is now considerable evidence that rheumatoid disease itself plays an important role in the aetiology of the NHL. The increased risk . . . [Full Text of this Article]


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