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Rheumatology Advance Access originally published online on August 20, 2009
Rheumatology 2009 48(11):1462-1463; doi:10.1093/rheumatology/kep247
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Epstein–Barr virus-associated lymphoma in patients with dermatomyositis. Be aware of double immunosuppression

Albert Selva-O’Callaghan1, Andrés Palacios2, Roser Solans-Laque1, Anne Labirua1, Teresa Salcedo-Allende3 and Miquel Vilardell-Tarrés1

1Internal Medicine Department, 2Hematology Department and 3Pathology Department, Vall D’Hebron General Hospital, Barcelona, Spain

Correspondence to: Albert Selva-O’Callaghan, C/Siracusa No. 12, BIS ‘A’, Barcelona 08012, Spain. E-mail: aselva@vhebron.net

The first 10% of the full text of this article appears below.


   Introduction
 
SIR, We present the case of two patients with DM treated with prolonged double-agent immunosuppressive therapy, who developed fatal Epstein–Barr virus (EBV)-associated lymphoproliferative disease.


   Case 1
 
A 33-year-old woman was hospitalized for persistent fever over the previous week. She had been diagnosed with DM at another hospital in 1999. Muscle biopsy showed characteristic findings, and cancer screening, including a complete physical examination, laboratory tests (haematocrit, serum chemistry panel and tumour markers), thoraco-abdominal CT, gynaecological ultrasound and mammography, was negative. Because of corticosteroid-refractory . . . [Full Text of this Article]


   Case 2
 

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