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Rheumatology Advance Access originally published online on March 1, 2009
Rheumatology 2009 48(5):594-595; doi:10.1093/rheumatology/kep027
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Poor response of anti-SRP-positive idiopathic immune myositis to B-cell depletion

Bryan R. Whelan1 and David A. Isenberg1

1Centre for Rheumatology, University College London, London, UK

Correspondence to: David A. Isenberg, Centre for Rheumatology, University College London, The Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK. E-mail: d.isenberg@ucl.ac.uk

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SIR, Antibodies to signal recognition particles (SRPs), cytoplasmic proteins involved in the recognition and targeting of signals to the endoplasmic reticulum, were first reported in association with polymyositis (PM) in a 50-year-old woman by Reeves et al. in 1986 [1]. We present our experience of the difficulty in treating two patients with anti-SRP-positive myopathy.

A 44-year-old Caucasian woman developed symptoms of muscle weakness of her shoulder and hip girdles with rapid onset of associated atrophy. Hypothyroidism . . . [Full Text of this Article]


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