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Rheumatology Advance Access originally published online on May 11, 2009
Rheumatology 2009 48(7):858-859; doi:10.1093/rheumatology/kep097
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Tacrolimus—a potential therapy for polymyositis?

Lucy E. Waite1 and Rajan Madhok1

1Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK

Correspondence to: Lucy E. Waite, Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 84 Castle Street, Glasgow, UK. E-mail: lucywaite@doctors.org.uk

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SIR, The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of disorders and the cornerstone of treatment for the IIMs is corticosteroids, often in combination with a conventional immunosuppressant agent. We report three cases of IIM treated successfully with tacrolimus. Patient 1 was a 48-year-old woman with undifferentiated connective tissue disease, diagnosed on the basis of interstitial lung disease (ILD), telangiectasia, sclerodactyly, RP, dysphagia, arthralgia and myalgia. Immunology was negative. Serum creatinine phosphokinase (CK) was elevated at 1520 U/l, EMG studies, MRI and . . . [Full Text of this Article]


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