Rheumatology Advance Access originally published online on May 20, 2009
Rheumatology 2009 48(7):862-863; doi:10.1093/rheumatology/kep123
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Acute gout during treatment with paclitaxel for metastatic melanoma
1Georgetown Dermatology, Washington, DC,2Medistem Inc., San Diego, CA,3Department of Medicine, Division of Dermatology, University of California at San Diego, La Jolla, CA and 4Department of Hematology-Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
Correspondence to: Doru T. Alexandrescu, Georgetown Dermatology, 140 Michigan Avenue NE T44, Washington, DC 20017, USA. E-mail: mddoru@hotmail.com
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SIR, Gout is caused by extracellular urate supersaturation and precipitation in the articular cartilages, tendons or surrounding tissues. Hyperuricaemia is associated with the treatment of fast-growing malignancies, particularly haematological neoplasms. We present a case of acute gout precipitated by the chemotherapeutic agent paclitaxel, used for the treatment of metastatic melanoma, which occurred in the absence of tumour lysis syndrome.
A 61-year-old male with metastatic melanoma and a longstanding mild idiopathic gout presented for a pulmonary metastatic relapse. His gout, of