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Editorial |
Translating ideas into progress in systemic sclerosis
1Department of Internal Medicine and Immunopathology, Hospital Cochin, Paris, France
Correspondence to: L. Guillevin, Service de Médecine Interne, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris René Descartes, 27 rue du Faubourg Saint- Jacques, 75014 Paris, France. E-mail: loic.guillevin@cch.aphp.fr
| The first 150 words of the full text of this article appear below. |
The papers in this supplement to Rheumatology have addressed current knowledge of the pathogenesis of SSc and its associated complications, alongside practical issues of disease management. As our colleagues illustrate, the last 10 years of partnership and research have ushered in a new era of progress in the field of SSc. The expansion of our understanding of SSc pathophysiology has, in turn, led to the development of advanced therapies that have improved prognosis and survival. Despite this, considerable challenges remain in developing our understanding of this disease further and in managing patients with SSc.
Our current understanding
The pathogenesis of SSc is complex, and appears to involve the endothelium, fibroblasts and immunological mediators [1]. An early, and possibly initiating, event is endothelial
The next 10 years