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Rheumatology Advance Access published online on April 27, 2008
Rheumatology, doi:10.1093/rheumatology/ken135
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Autoimmunity manifesting as dermatomyositis associated with oligoastrocytoma and dendritic cell immunotherapy

E. C. Derrett-Smith and D. A. Isenberg

Centre for Rheumatology, University College Hospitals NHS Foundation Trust, London, UK

Correspondence to: E. C. Derrett-Smith, UCL-Centre for Rheumatology, Hampstead Campus Royal Free and University College London Medical School, London NW3 2PF, UK. E-mail: e.derrett-smith@medsch.ucl.ac.uk

The first 10% of the full text of this article appears below.

SIR, A case of severe dermatomyositis occurring after completion of dendritic cell (DC) immunotherapy as a treatment for grade II oligoastrocytoma is described. This is the first report to our knowledge of dermatomyositis associated with either a primary brain tumour or DC immunotherapy.

A 39-yr-old man presented with a 4-week history of muscle pain and weakness, fatigue, fever and a rash. He had been fit and well, and was a keen athlete until a year prior to this presentation when he had been diagnosed with a grade II oligoastrocytoma. This had been debulked 6 months earlier, with 85% clearance and minimal neurological deficit. No further conventional . . . [Full Text of this Article]


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