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Rheumatology Advance Access published online on April 24, 2008
Rheumatology, doi:10.1093/rheumatology/ken147
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Tubulointerstitial nephritis uveitis syndrome associated with erosive arthropathy of the hip

P. Mangat, A. S. M. Jawad and W. Brownlee

The Royal London Hospital, London, UK

Correspondence to: A. S. M. Jawad, The Royal London Hospital, Bancroft Road, London, E1 4DG, UK. E-mail: alismjawad1@hotmail.com

The first 10% of the full text of this article appears below.

SIR, In 1975, Dobrin et al. [1] described tubulointerstitial nephritis uveitis syndrome (TINU) in two women with anterior uveitis and tubulointerstitial nephritis. Since then ~140 cases have been described in the literature.

The pathogenesis of TINU is poorly understood. Suppression of peripheral cell-mediated immunity leading to skin anergy and locally increased immune reactivity, analogous to sarcoidosis, is likely to play a significant role. This local proliferation of T helper cells also occurs in SS suggesting that similar physiopathogenic mechanisms may act across these three diseases [2–5]. Unlike SS and sarcoidosis, TINU is not known to be associated with arthritis. We present a case of TINU in association with an erosive arthropathy of the hip, a feature that has not been previously described.

A 56-yr-old lady presented with a 4-month history of malaise, abdominal and flank pain. Serum . . . [Full Text of this Article]


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