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Rheumatology Advance Access originally published online on June 23, 2009
Rheumatology 2009 48(9):1168-1169; doi:10.1093/rheumatology/kep159
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Catastrophic anti-phospholipid syndrome associated with Escherichia coli O157 infection

Masaki Shimizu1, Masahide Yamazaki2, Toru Horisawa1, Akiko Seno3, Kazuhide Ohta4, Kengo Furuichi5 and Akihiro Yachie1

1Department of Paediatrics, 2Department of Cellular Transplantation Biology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 3Department of Paediatrics, Kanazawa Red Cross Hospital, 4Department of Paediatrics, Kanazawa Medical Center and 5Department of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan

Correspondence to: Masaki Shimizu, Department of Paediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8641, Japan. E-mail: mshimizu@ped.m.kanazawa-u.ac.jp

The first 10% of the full text of this article appears below.

SIR, Catastrophic APS (CAPS) is a term applied to aPL-mediated disorder in which multiple thrombi of small vessels affect the viscera over a relatively short period [1–3]. CAPS is rare in children and may be confused with haemolytic-uraemic syndrome (HUS)/thrombotic thrombocytopenic purpura (TTP) because of similar clinical manifestations. More importantly, it will be easily overlooked if associated with an acute episode of HUS/TTP itself.

We describe the case of a 9-year-old girl with haemorrhagic colitis caused by Escherichia coli O157 who . . . [Full Text of this Article]


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