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Rheumatology 2001; 40: 360
© 2001 British Society for Rheumatology

Robin Goodfellow

Yee-hah, line dancers. No need to fear that you will have to give up for fear of developing osteoarthritis of the hip—unless it runs in the family. The Nottingham group (Lanyon et al., Br Med J 2000;321:1179–83) [Abstract/Free Full Text] show that there is a strong genetic influence, with a high risk of hip osteoarthritis (OA) in siblings. Mind you, given that overuse may contribute to damage, it might be worth comparing line dancers with their non-dancing brothers and sisters.


Osteoarthritis is attracting lots of interest at last. A large conference at the National Institutes of Health has been reported (Ann Intern Med 2000;133:635–46—for part 1, which covers the condition and risk factors).[Abstract/Free Full Text] Entitled ‘Stepping away from OA: prevention of onset, progression and disability of osteoarthritis’ the conference has come up with a number of research suggestions which can be seen at: www.nih.gov/niams/reports/oa/ oareport.htm

Lastly on OA Robin found an appraisal of the use of glucosamine and chondroitin in one of the new reviews of reviews of reviews journals (Evidence-Based Nursing 2000;3:124) [Free Full Text] which summarizes the review by McAlindon et al. (J Am Med Assoc 2000;283:1469–75).[Abstract/Free Full Text] The conclusion of the meta-analysis is that there may be benefit, but the magnitude of it is unclear. Interestingly for those who like to remind patients that ‘natural’ remedies are not always safe, there is some evidence that glucosamine may induce insulin resistance (Heart et al., Am J Physiol Endocrinol Metab 2000;278:E103–12) [Abstract/Free Full Text] so we had better, perhaps, watch our glucosamine patients for evidence of diabetes. Robin prefers to suggest to patients that their money might be better enjoyed if they purchased a bottle of claret.

Occasionally Robin goes hunting for malignancy in the patient with unexplained rheumatological manifestations or funny blood tests. A new review of paraneoplastic syndromes has recently appeared (Fam Clin Rheumatol 2000;14:515–33) which is quite useful. It would however, have been more helpful if it had included a list of cancers and the syndromes associated with them. Robin spent ages trying to track down whether uterine cancer was so associated, his friendly gynaecologists having denied all knowledge (it is, but he will leave the fun of discovery to y'all). And when did the Eaton–Lambert syndrome become the Lambert–Eaton syndrome? This eponymous fiddling gets on Robin's nerves (he was taught about Jakob–Creutzfeldt disease, which reversed to become CJD, but feels the biscuit must go to the Plummer–Vinson–Paterson–Brown–Kelly syndrome).

Robin's use of needles in gout is confined to aspiration of a joint to prove the diagnosis but an unusual paper appeared in Acupuncture in Medicine (Pang et al., 2000; 18:29–31) suggesting benefit from the traditional Chinese technique, both in reduction of attack frequency and in uric acid levels. The methodology is slightly suspect; diagnosis was made on clinical grounds alone and some of the records were lost in transit between Zanzibar, where the study was done, and China.

Robin wonders whether NICE should look at the cost-effectiveness analysis by Choi, Seeger and Kuntz (Arthritis Rheum 2000;43:2316–27).[Web of Science][Medline] The study examined treatment of methotrexate resistant arthritis; it concluded that in a methotrexate-naïve patient the cost of achieving an ACR-70 response over 6 months with 15 mg methotrexate weekly was US$1500, while methotrexate with etanercept came out at US$34800. Is this acceptable, they ask? This depends, Robin imagines, on whether you are a patient or a Health Authority Chief Executive. If you are both, a psychiatrist might be required.

Two papers on examination caught Robin's eye; the first entitled ‘How I examine the knee’ (Bollen, Curr Orthop 2000;14:189–92). It is a useful guide especially for ligament testing, although his test for loss of extension (‘picking up the limbs by the toes will identify any difference ...’) would bring tears to most of Robin's RA patients. Somewhat surprisingly the still pictures and the descriptions do convey the message clearly (try writing down how to tie a tie). This could not be said of an illustrated tutorial of musculoskeletal sonography (Part 3, lower extremity, by Lin et al., Am J Roentgenol 2000;175:1313–21).[Free Full Text] The multitude of pictures covered with arrows and annotations mean nothing even to this denizen of the dark. Robin has watched his radiology colleagues doing ultrasound and even then he cannot understand what he is looking at; it reminds him of those pictures that appear by magic when you rub a pencil over a blank page.

A timely review of recent advances in rheumatology (Madhok, Kerr and Capell, Br Med J 2000;321:882–5) [Free Full Text] appeared recently. It reinforces some important points for a non-rheumatological audience, in particular that weight loss helps in OA, that quads exercises help in knee OA and that early disease-modifying anti-rheumatic drug use improves the outcome in rheumatoid arthritis (RA). Perhaps this will lead to a change in balance of Robin's clinics. He was proposing to offer access within a week for RA patients, but to refuse to see OA patients unless their symptoms persisted despite weight reduction of at least 6 kg, and documented evidence that they did their knee exercises twice daily. Just as he reached the decision that all patients should also stop smoking he woke up and realized that it was time to go to work. Bye for now.


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