Rheumatology 2001; 40: 1078
© 2001 British Society for Rheumatology
Corrigendum
Keen RW, Snieder H, Molloy H, Daniels J, Chiano M, Gibson F, Fairbairn L, Smith P, MacGregor AJ, Gewert D, Spector TD. Evidence of association and linkage disequilibrium between a novel polymorphism in the transforming growth factor ß1 gene and hip bone mineral density: a study of female twins. Rheumatology 2001;40:48–54.
A coding error has occurred in the preparation of the above manuscript. This led to the C allele of the polymorphism being called the T allele and vice versa. The results and implications of the study are the same, but the allele frequencies are different and throughout the paper ‘C allele’ should read ‘T allele’. This means that the results section of the abstract should read as follows:
Results. A C 
T polymorphism was identified in intron 5, the T allele having a frequency of 0.25. Subjects homozygous for the presence of the TGF-ß1 T allele had a 4% reduction in femoral neck BMD compared with the other two genotype groups (P<0.025). No effect was seen at the lumbar spine or ultradistal radius, or with calcaneal ultrasound measurements. Results were unaffected after adjustment for potential confounders. These findings were predominantly seen in pre-menopausal subjects, suggesting that this locus has an effect on the attainment of peak BMD. In pre-menopausal women, subjects who were homozygous for the T allele had a 5-fold excess risk of having osteoporosis at the femoral neck compared with the other genotype groups.
Page 49, column 2, the last sentence of the paragraph entitled: ‘Bst UI PCR–RFLP analysis of the intron 5 SNP’ should read: Alleles were coded as follows: A1=presence of restriction site; A2=absence of site.
Page 52, column 2, last line, ‘CC’ should read ‘TT’.
CiteULike 
Connotea 
Del.icio.us What's this?
| ||||||||||||||||||||||||||||||||||||||||||||||