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Rheumatology 2003; 42: 491
© 2003 British Society for Rheumatology

Letters to the Editor

Pamidronate for SAPHO syndrome

A. J. Crisp

Addenbrooke's Hospital, Cambridge, UK

SIR, Marshall et al. [1] propose pamidronate as a novel treatment for SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) but we reported effective relief of pain for 3 months with a single infusion of 60 mg pamidronate in a patient under my care in a series of four patients in 1993 [2]. I prefer the term ‘arthro-osteitis' to ‘SAPHO syndrome’ as synovitis, acne and pustulosis are not sine qua non features of this rare condition. Pamidronate can be repeated safely when pain recurs, and it has become a useful treatment.

Notes

E-mail: ajcrisp{at}addenbrookes.nhs.uk Back

References

  1. Marshall H, Bromilow J, Thomas AL, Arden NK. Pamidronate: a novel treatment for the SAPHO syndrome? Rheumatology 2002;41:231–3.[Free Full Text]
  2. Watts RA, Crisp AJ, Daunt SO'N, Hazleman BL, Jenner JR. Arthro-osteitis: a clinical spectrum. Br J Rheumatol 1993;32:403–7.[Abstract/Free Full Text]
Accepted 13 September 2002


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