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Rheumatology Advance Access originally published online on February 21, 2006
Rheumatology 2006 45(5):645-646; doi:10.1093/rheumatology/kel033
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

LETTER TO THE EDITOR

ß2-Glycoprotein I IgA antibodies and ischaemic stroke

H. L. Staub, C. A. von Muhlen and G. L. Norman1

Rheumatology Department, Saint Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil and 1 INOVA Diagnostics, San Diego, CA, USA

Correspondence to: H. L. Staub, Rheumatology Department, Saint Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Av. Ipiranga 6690/220, Porto Alegre Rio Grande do Sul 90610-000. Brazil. E-mail: henriquestaub{at}terra.com.br

SIR, Regarding the article by Kahles et al., recently published in this journal [1], we would like to point out that our previous paper, published in 2003 [2] and not referred to by Kahles et al., had already shown an association of IgA antibodies to ß2-glycoprotein I (ß2gpI) with ischaemic stroke. Like Kahles et al., we conducted a case–control study with multivariate analysis. This also allowed us to evaluate risk association after adjustment for known risk factors for stroke. Our data showed that the presence of IgA anti-ß2gpI antibodies was independently associated with the risk of acute cerebral ischaemia (adjusted odds ratio 4.6; 90% confidence interval 1.5–14.3; P = 0.025). ß2gpI is present in atheroma plaques [3]. The occurrence of IgA anti-ß2gpI antibodies in patients with ischaemic stroke brings about a possible link of autoimmunity with thrombophilia and/or atherosclerosis.

G.L.N. is an employee of INOVA Diagnostics Inc. He does not hold any stock or equity interest in the company.

References

  1. Kahles T, Humpich M, Steinmetz H, Sitzer M, Lindhoff-Last E. Phosphatidylserine IgG and beta2-glycoprotein I IgA antibodies may be a risk factor for ischaemic stroke. Rheumatology 2005;44:1161–5.[Abstract/Free Full Text]
  2. Staub HL, Norman GL, Crowther T et al. Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischaemia. Arq Neuropsiquiatr 2003;61:757–63.[Medline]
  3. George J, Harats D, Gilburd B et al. Immunolocalization of beta2-gpI(apolipoprotein H) to human atherosclerotic plaques: potential implications for lesion progression. Circulation 1999;99:2227–30.[Abstract/Free Full Text]
Accepted 6 January 2006


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This Article
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