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© 1980 British Society for Rheumatology

research-article

INTRA-ARTICULAR STEROIDS IN OSTEOARTHRITIS*

P. A. DIEPPE, B. SATHAPATAYAVONGS, H. E. JONES, P. A. BACON and E. F. J. RING

University Department of Medicine Bristol Royal Infirmary Bristol BS2 8HW and Royal National Hospital for Rheumatic Diseases Bath

Correspondence to: Requests for reprints to P. A. Dieppe, Bristol Royal Infirmary.

Intra-articular steroid therapy for osteoarthritis of the knee has been reassessed by two placebo-controlled trials of 20 mg of triamcinalone hexacetonide in 48 joints. Steroid injections caused a significantly greater reduction in pain and tenderness than placebo, and were preferred by patients. However, the benefits were small and transient. Maximum pain reduction occurred one week after injection, and was accompanied by a fall in the thermographic index suggesting an anti-inflammatory mode of action. Synovial fluid was unaffected by injections, and there was no correlation between synovial fluid cell counts or the radiological grading, and the degree of pain reduction.

*Some of these data formed part of a paper presented to the Heberden Society Meeting in Bath, in March 1979.


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