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© 1983 British Society for Rheumatology

research-article

MUSCLE CHANGES IN ANKYLOSING SPONDYLITIS

G. O. HOPKINS1, J. MCDOUGALL2, K. R. MILLS2, D. A. ISENBERG2 and A. EBRINGER1,3,

1Department of Rheumatology, The Middlesex Hospital London W1P 9PG
2Department of Morbid Anatomy, Medicine and Rheumatology, University College Hospital London
3Immunology Unit, Department of Biochemistry, Queen Elizabeth College London W8 7AH

Correspondence to: Address correspondence to Dr.A. Ebringer, Department of Rheumatology, The Middlesex Hospital, London W1P 9PG.

Muscle biopsy of the quadriceps femoris was carried out in 20 patients with classical ankylosing spondylitis (AS). Histological and histochemical studies revealed changes in all biopsies to a varying degree. Central migration of nuclei was present in 80%, reduced fibre size with some atrophy in 40%, localized reaction to acid phosphatase in 75% and a peripheral condensation of reaction product to NADH-TR stain in 55% of biopsies. Furthermore 14 out of 16 patients, whose quadriceps strength was measured, were found to be below the predicted values, when compared to healthy controls of similar weight, and quantitative surface electromyography in 10 showed lower mean power frequency than in controls. A raised plasma creatine kinase was found in only two patients. It is concluded that muscle changes occur in AS and these may account for some of the clinical features of the disease.

KEY WORDS: Ankylosing spondylitis, Muscle changes


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