Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by KAY, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KAY, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1986 British Society for Rheumatology

research-article

EUROPEAN LEAGUE AGAINST RHEUMATISM STUDY OF ADVERSE REACTIONS TO D-PENICILLAMINE

A. KAY

ARC Epidemiology Unit and Department of Rheumatology, Guy's Hospital London SE1 9RT, UK

An international multicentre study of adverse reactions to D-penicillamine was undertaken on 2879 patients exposed to the drug—1491 of them a prospective sample. The majority of patients were being treated for rheumatoid arthritis. Over a period of 18 months, 319 (21%) of patients in the prospective sample developed adverse reactions necessitating drug withdrawal; two thirds of these occurred during the first 3 months of treatment. The most frequently-occurring adverse reactions involved skin (6%), kidneys (4%), gastro-intestinal tract (4%) and haemopoiesis (3%). Adverse effects, considered to be serious by the reporting physician, included fever and leucopenia during the early weeks of treatment and, after some months of drug exposure, proteinuria, myasthenia gravis, dyspnoea and pemphigus. Two patients died, one of fulminating septicaemia and the other was found at autopsy to have had multiple lung abscesses following unexplained anaemia and hemiparesis.

KEY WORDS: D-Penicillamine, Rheumatoid arthritis, Adverse drug reaction


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch DermatolHome page
T. W. McGovern and S. D. Bennion
Diffuse Blisters and Erosions in a Patient With Limited Scleroderma
Arch Dermatol, April 1, 1997; 133(4): 504 - 504.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.