Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by SILVERMAN, B.
Right arrow Articles by HAZLEMAN, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SILVERMAN, B.
Right arrow Articles by HAZLEMAN, B. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 British Society for Rheumatology

other

THE SULPHATED GLYCOSAMINOGLYCAN LEVELS IN SYNOVIAL FLUID ASPIRATES IN PATIENTS WITH ACUTE AND CHRONIC JOINT DISEASE

B. SILVERMAN, T. E. CAWSTON, D. P. PAGE THOMAS*, J. T. DINGLE* and B. L. HAZLEMAN

Rheumatology Research Unit Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ
*Strangeways Research Laboratory Wort's Causeway, Cambridge

Correspondence to: Correspondence to Dr B. Silverman

Proteoglycan levels were measured in a series of synovial fluid samples from patients with acute and chronic joint diseases using a modified chemical dye binding method. Levels found in 50 miscellaneous inflammatory arthritis fluids (mean = 173.2±90.9 µg/ml) were higher than found in either 50 with rheumatoid arthritis (96.3±31.3 µg/ml) or 50 with osteo-arthritis (83.8±27.3 µg/ml). For comparison, proteoglycan levels were measured in 15 cadaver synovial fluids (98.9±44.2 µg/ml) and 12 synovial fluids from patients with sports injury (163.7179.4 µg/ml).

Patients were recruited into a trial where synovial fluid was aspirated as often as possible over a 6-month period during which the patients were followed using a number of well proven clinical parameters. No correlation was found between the degree of joint destruction as measured by X-ray damage and the concentration or total amount of proteoglycan in the synovial fluid. In addition, there was no correlation between the level or total amount of proteoglycan and any clinical parameter of disease activity

KEY WORDS: Proteoglycan, Cartilage, Arthritic diseases, Synovial fluid


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
C. Belcher, R. Yaqub, F. Fawthrop, M. Bayliss, and M. Doherty
Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees
Ann Rheum Dis, May 1, 1997; 56(5): 299 - 307.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.