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© 1990 British Society for Rheumatology

other

SPECIFIC ANTIBODY RESPONSE TO THE MYCOBACTERIAL 65 kDa STRESS PROTEIN IN ANKYLOSING SPONDYLITIS AND RHEUMATOID ARTHRITIS

I. L. McLEAN*,, J. R. ARCHER, M. I. D. CAWLEY{dagger}, F. S. PEGLEY, B. L. KIDD and P. W. THOMPSON

The Inflammation Group, London Hospital Medical College Turner Street, London E1 2AD
{dagger}Rheumatology Department, Southampton General Hospital Southampton SO9 4XY

Correspondence to: *Present address: Division of Immunological Medicine, MRC Clinical Research Centre. Watford Rd, Harrow HA1 3UJ.

Correspondence to: Correspondence to Dr I. McLean

Immune responses to conserved, immunogenic homologues of the mycobacterial 65 kDa stress protein (SF65) have been implicated in inflammatory arthritis. Serum anti-SP65 was measured in AS, RA and healthy controls using an indirect enzyme immunoassay with recombinant SP65. IgA anti-SP65 was elevated in 19 of 59 AS patients, but the elevation in median level was not statistically significant. Anti-SP65 of all isotypes was increased in RA, but achieved significance (P<0.01) for IgA only. Adjusting specific antibody results for elevations in total serum Ig levels reduced AS and RA anti SP65 to near normal levels, suggesting that a major component of the increased anti-SP65 may be secondary to polyclonal activation.

KEY WORDS: Autoimmunity, Heat shock, Stress protein, Ankylosing spondylitis, Rheumatoid arthritis


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