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© 1991 British Society for Rheumatology

brief-report

IMMUNOGLOBULIN HEAVY CHAIN GENE POLYMORPHISMS IN ITALIAN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS

L. I. SAKKAS, A. MARCHESONI*, L.-A. KERR, R. RANZA*, B. COLOMBO*, K. I. WELSH and G. S. PANAYI

Molecular Immunogenetics and Rheumatology Units, Division of Medicine, UMDS, Guy's Hospital London
*Instituto Ortopedico G. Pini Milan, Italy

Correspondence to: Correspondence to Prof. G. Panayi, Rheumatology Unit, Division of Medicine, 4th Floor, Hunts House, Guy's Hospital, London SE1

A polymorphism of the switch region of the µ IgH gene (Sµ) is associated with arthritis in English patients with psoriasis. In this study, Italian patients with psoriasis alone (PS) or psoriatic arthritis (PSA) were analysed by Southern blot using DNA probes for the Sµ region and a hypervariable locus 5' of the joining (JH) region of IgH (5' JH). No association between PSA and IgH gene polymorphisms was found. However, an association was found between PS and a genotype of the 5' JH region (Fisher's P = 0.0002, RR = 27). Additional DNA markers around the Sµ region may reveal more accurate markers for PS or PSA.

KEY WORDS: Immunoglobulin heavy chain gene, Restriction fragment length polymorphism, Psoriatic arthritis, Psoriasis


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