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© 1992 British Society for Rheumatology

other

ANTI-PROTEUS ANTIBODIES IN RHEUMATOID ARTHRITIS SAME-SEXED SIBSHIPS

C. M. DEIGHTON*,, J. W. GRAY{dagger}, A. J. BINT{dagger} and D. J. WALKER*

*Department of Rheumatology, Royal Victoria Infirmary Newcastle-upon-Tyne NE1 4LP
{dagger}Department of Microbiology, Royal Victoria Infirmary Newcastle-upon-Tyne NE1 4LP

Correspondence to: Correspondence to C. M. Deighton

One hundred and forty-two RA patients and 121 of their healthy same-sexed siblings were tested for antibodies (Abs) to Proteus mirabilis and Escherichia coli by indirect immunofluorescence. Eighty-five individuals had active RA (CRP>10 mg/l) and 57 inactive RA. The anti-Proteus Ab titre in the active RA group was significantly higher than in the inactive RA and non-RA group (P<0.0001 in both cases). Anti-Proteus Abs were significantly elevated in 30 individuals with active RA compared with their healthy HLA-identical same-sexed siblings (P>0.001). In 42 HLA-DR4 positive and 15 HLA-DR4 negative active RA patients, the Ab titre was non-significantly higher in the former group. Anti-E. coli Abs were not significantly elevated in any of the groups. Longitudinal data on 36 RA patients demonstrated a significant positive correlation between changes in CRP and changes in anti-Proteus antibody titres (r=0.52, P<0.001). These observations require an explanation.

KEY WORDS: Active disease, Inactive disease, HLA-identical, HLA-DR4, Escherichia coli, C-reactive protein, Rheumatoid factor


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