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© 1993 British Society for Rheumatology

research-article

VIRUS-LIKE PARTICLES IN SYNOVIAL FLUIDS FROM PATIENTS WITH RHEUMATOID ARTHRITIS

G. STRANSKY, J. VERNON, W. K. AICHER, L. W. MORELAND, R. E. GAY and S. GAY

Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham Birmingham, Alabama, USA

Based on the elevated expression of oncogenes in proliferating transformed-appearing synoviocytes we searched for the possible involvement of a viral agent in the pathogenesis of RA. We report the detection of virus-like particles with retro viral C type morphology in SF, which lack the typical morphologic as well as immunohistochemical features of the human T-lymphotropic and immunodeficiency viruses.

KEY WORDS: Rhcumatoid arthritis, Virus, Joint fluid


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