Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HELIÖVAARA, M.
Right arrow Articles by AROMAA, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HELIÖVAARA, M.
Right arrow Articles by AROMAA, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1996 British Society for Rheumatology

other

SERUM CHOLESTEROL AND RISK OF RHEUMATOID ARTHRITIS IN A COHORT OF 52 800 MEN AND WOMEN

M. HELIÖVAARA*,{dagger},, K. AHO*, P. KNEKT*,{dagger}, A. REUNAMEN*,{dagger} and A. AROMAA*,{dagger}

*National Public Health Institute Helsinki, Finland
{dagger}Social Insurance Institution Helsinki, Finland

Correspondence to: Correspondence to: M. Heliövaara, National Public Health Institute, Mannerheunintie 166, FIN-00300 Helsinki, Finland.

Recent epidemiological studies have suggested that joint risk factors occur for rheumatoid arthritis (RA) and coronary heart disease. We studied serum cholesterol concentration for its association with the incidence of RA in 28 362 men and 24 444 women free from arthritis at baseline. During a mean follow-up of 21 yr, 161 men and 351 women developed RA. Of these incident cases, 119 men and 229 women were rheumatoid factor (RF) positive. The serum cholesterol concentration was directly proportional to the risk of RF-positive RA among women and RF-negative RA among men; the age-adjusted relative risks (95% confidence intervals) per S.D. (1.4mM/l) of the cholesterol distribution were 1.20 (1.05–1.38) and 1.56 (1.15–2.10), respectively. No association was observed, however, for RF-negative RA among women or RF-positive RA among men. The results suggest that a still unknown factor closely associated with serum cholesterol may be involved in the aetiology of RA, but complex interactions with sex and RF status seem to occur.

KEY WORDS: Epidemiology, Longitudinal studies, Cholesterol, Rheumatoid arthritis, Rheumatoid factor, Risk factors


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
D H Solomon, N J Goodson, J N Katz, M E Weinblatt, J Avorn, S Setoguchi, C Canning, and S Schneeweiss
Patterns of cardiovascular risk in rheumatoid arthritis
Ann Rheum Dis, December 1, 2006; 65(12): 1608 - 1612.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
N. J. Goodson, A. J. Silman, D. J. Pattison, M. Lunt, D. Bunn, R. Luben, N. Day, K.-T. Khaw, and D. P. M. Symmons
Traditional cardiovascular risk factors measured prior to the onset of inflammatory polyarthritis
Rheumatology, June 1, 2004; 43(6): 731 - 736.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
N. Busso, J. Dudler, R. Salvi, V. Peclat, V. Lenain, S. Marcovina, R. Darioli, P. Nicod, A. K. So, and V. Mooser
Plasma Apolipoprotein(a) Co-Deposits with Fibrin in Inflammatory Arthritic Joints
Am. J. Pathol., October 1, 2001; 159(4): 1445 - 1453.
[Abstract] [Full Text]

Home page
 Rheumatology (Oxford)Home page
P. H. Dessein, A. E. Stanwix, Z. Moomal, D. Symmons, and B. Harrison
Rheumatoid arthritis and cardiovascular disease may share similar risk factors
Rheumatology, June 1, 2001; 40(6): 703 - 704.
[Full Text] [PDF]

Home page
 Ann Rheum DisHome page
M Heliövaara, K Aho, P Knekt, O Impivaara, A Reunanen, and A Aromaa
Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis
Ann Rheum Dis, August 1, 2000; 59(8): 631 - 635.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.