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The British Journal of Rheumatology, Vol 36, 990-995, Copyright © 1997 by British Society for Rheumatology

ORIGINAL PAPERS

Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process

JG Tebib, C Reynaud, JP Cedoz, MC Letroublon and A Niveleau
CHLS, Pierre Benite, France.

The levels of the five methylated nucleosides pseudouridine (psi-Urd), 1-methyladenosine (1-MeAdo), 4 acetylcytidine (4-AcCyd), 1 methylinosine (1-Melno) and 7 methylguanosine (7-MeGuo) resulting from RNA degradation were examined in the urine of rheumatoid arthritis (RA) patients. Of these five, 1-MeAdo and psi-Urd were correlated with the active phase of the disease, while two others (4-AcCyd and 1-Melno), which require further evaluation, appeared to be linked to the prognosis of the disease. As RNA turnover is closely associated with cell proliferation, including that of lymphocytes in RA, there may be a hitherto unsuspected benefit in measuring 1-MeAdo and psi-Urd as biochemical markers of RA disease activity.
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