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Rheumatology 1999; 38: 1025-1027
© 1999 British Society for Rheumatology

Letters to the Editor

A search for Pneumocystis carinii DNA by polymerase chain reaction on bronchoalveolar lavage fluids from patients with Wegener's granulomatosis

G. Nevez, A. Pruna 1, V. Jounieaux 2, R. Makdassi 1, A. Totet and C. Raccurt

Department of Parasitology, Mycology and Travel Medicine,
1 Department of Internal Medicine and
2 Department of Pneumology, Regional University Hospital-South Hospital Centre, 80054 Amiens, France

Correspondence to: G. Nevez, Department of Parasitology, Mycology and Travel Medicine, Regional University Hospital-South Hospital Centre, 80054 Amiens, France

SIR, Recently, involvement of Pneumocystis carinii in the aetiology of Wegener's granulomatosis (WG) was suggested. Indeed, co-trimoxazole efficacy in the prophylaxis of relapses of this granulomatosis was reported [1]. Varela et al. [2] investigated the presence of the parasite in the lungs of four patients with WG using immunoperoxidase assay. Microscopic examination of three open lung biopsies and one post-mortem lung fragment remained negative despite the high sensitivity of the immunodetection. These data were not . . . [Full Text of this Article]

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