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Rheumatology 1999; 38: 1145-1149
© 1999 British Society for Rheumatology

Polyarticular heterotopic ossification complicating critical illness

J. W. G. Jacobs, P. B. J. De Sonnaville2, H. M. J. Hulsmans, A. C. van Rinsum1 and J. W. J. Bijlsma

Department of Rheumatology & Clinical Immunology,
1 Department of Orthopaedic Surgery, University Medical Centre, PO Box 85500, 3508 GA Utrecht and
2 Hospital `Oosterschelde', 's Gravenpolderseweg 114, 4462 RA Goes, The Netherlands

Correspondence to: J. W. G. Jacobs.

A patient with generalized heterotopic ossification (HO) complicating critical illness due to necrotizing pancreatitis is described; data on two other cases with HO are briefly presented. The clinical features, prevention and therapy of HO are discussed. The effect of surgical therapy of the HO in our three patients was good.

KEY WORDS: Heterotopic ossification, Heterotopic/ectopic bone formation, Pancreatitis, Abdominal surgery, Mechanical ventilation, Prevention, NSAIDs, Bisphosphonates, Therapy.


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