Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tyndall, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tyndall, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 1999; 38: 774-776
© 1999 British Society for Rheumatology

Paediatric Rheumatology: Autologous Stem Cell Transplantation in Rheumatic Diseases of Childhood

Haematological stem cell transplantation in the treatment of severe autoimmune diseases: first experiences from an international project

Series Editor: P. Woo

A. Tyndall

Department of Rheumatology, University Hospital Felix Platter Spital, Burgfelderstrasse 101, Basel 4012, Switzerland

The use of profound immunosuppression in the treatment of severe autoimmune disease (AD) is routine. Experience ranges from the use of established regimens of cyclophosphamide and prednisone in Wegener's granulomatosis (WG) and renal systemic lupus erythematosus (SLE), to anecdotal or experimental modalities in rarer disorders.

A common theme running through these experiences is the failure of `conventional' immunosuppression to control a life- or vital organ-threatening immunologically mediated event, and a lack of proven alternatives. Another recurring problem is the limitation of bone marrow toxicity related to the intensity of immunosuppression.

Recent developments in haemopoietic stem cell transplantation (HSCT) have brought a level of safety which allows it to be considered as a therapeutic option for AD treatment . . . [Full Text of this Article]

Bone marrow transplantation

Coincident autoimmune disease and BMT

Bone marrow transplantation for autoimmune disease alone

Outcome

Summary

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
W. Kuis, N. M. Wulffraat, and R. E. Petty
Autologous stem cell transplantation: an alternative for refractory juvenile chronic arthritis
Rheumatology, August 1, 1999; 38(8): 737 - 738.
[Full Text] [PDF]