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Rheumatology 1999; 38: 841-847
© 1999 British Society for Rheumatology

Relationship between soluble markers of immune activation and bone turnover in post-menopausal women with rheumatoid arthritis

P. Oelzner, S. Franke, A. Müller, G. Hein and G. Stein

Department of Internal Medicine IV, Friedrich-Schiller University of Jena, Germany

Correspondence to: P. Oelzner, Department of Internal Medicine IV, Friedrich-Schiller University of Jena, Erlanger Allee 101, 07740 Jena, Germany.

Objective. Regarding interactions between pro-inflammatory cytokines and bone metabolism in rheumatoid arthritis (RA), we investigated the relationship between the serum levels of interleukin (IL)-1ß, IL-6, soluble interleukin-2 receptor (sIL-2r), C-reactive protein (CRP), the vitamin D metabolites 25-hydroxyvitamin D3 (25OHD3 ) and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 ], intact parathyroid hormone (iPTH) as well as serum and urinary parameters of bone turnover in 74 post-menopausal women with RA.

Results. SIL-2r correlated negatively with 1,25(OH)2D3 (P<0.01), whereas IL-6 showed a positive correlation with urinary excretion of deoxypyridinoline–collagen cross-links (P<0.01). 1,25(OH)2D3 (P<0.01) and iPTH (P<0.01) were negatively related to CRP, whereas the urinary excretion of pyridinoline (P<0.01) and deoxypyridinoline (P<0.01)–collagen cross-links showed a positive correlation with CRP. 1,25(OH)2D3 (P<0.01) and iPTH (P<0.05) were positively related to bone alkaline phosphatase as a marker of osteoblast function.

Conclusion. Our data indicate that IL-6 is a critical determinant of increased bone resorption in post-menopausal RA women with high disease activity and that serum levels of 1,25(OH)2D3 are inversely related to T-cell activation.

KEY WORDS: Rheumatoid arthritis, Osteoporosis, Pro-inflammatory cytokines, Vitamin D, PTH.


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