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Rheumatology, Vol 38, 11-13, Copyright © 1999 by British Society for Rheumatology

ORIGINAL PAPERS

Effect of nimesulide on glucocorticoid receptor activity in human synovial fibroblasts

JP Pelletier, JA Di Battista, M Zhang, J Fernandes, N Alaaeddine and J Martel- Pelletier
Universite de Montreal and Unite de recherche en arthrose, Centre de recherche, Centre Hospitalier de l'Universite de Montreal, Quebec, Canada.

Fibroblasts from human synovial membranes were cultured with nimesulide, naproxen or dexamethasone. Nimesulide, but not naproxen, showed effects on the glucocorticoid system that may contribute importantly to its anti-inflammatory activity. Nimesulide at therapeutically relevant concentrations induced the intracellular phosphorylation and activation of glucocorticoid receptors, and activated their binding to the target genes. Naproxen or dexamethasone markedly reduced the number of glucocorticoid receptor binding sites, in contrast to nimesulide, which had no significant effect.
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